Shortly after reaching orbit, the STS-60 crew began checking Discovery’s systems and activating the commercially developed SPACEHAB laboratory module and several of its experiments. The crew also activated one group of the payload bay Getaway Special experiments.

SPACEHAB module experiments that were activated included the Organic Separations payload, which is designed to investigate cell separation techniques for possible pharmaceutical and biotechnology processing, and the Equipment for Controlled Liquid Phase Sintering Experiment package, a furnace designed to explore the possibilities of creating stronger, lighter and more durable metals for use in bearings, cutting tools and electronics. SPACEHAB middeck experiments that were activated included Immune-1, which will look at the immune systems of rats in orbit, and the Commercial Protein Crystal Growth package, which is attempting to grow large, well- ordered protein crystals so that their structures can be more easily studied.