Soyuz TMA-19M was a 2015 Russian Soyuz spaceflight to the International Space Station. It was launched on December 15, 2015 from Baikonur Cosmodrome, transporting three members of the Expedition 46 crew to the International Space Station. TMA-19M was the 128th flight of a Soyuz spacecraft since the first in 1967. The crew consisted of a Russian commander accompanied by American and British astronauts. The flight returned to Earth on June 18, 2016. The Soyuz TMA-19M descent module is now in the collection of the UK's Science Museum Group.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.