Soyuz TMA-12M was a 2014 flight to the International Space Station. It transported three members of the Expedition 39 crew to the International Space Station. TMA-12M was the 121st flight of a Soyuz spacecraft since the first in 1967 and the 38th Soyuz mission to the ISS.

After a successful launch on 25 March 2014, docking was scheduled to occur on 26 March via the relatively new six-hour duration orbital trajectory. In the event, one of the orbital burns scheduled to refine the trajectory did not occur as planned, due to an attitude control problem in which the spacecraft was incorrectly oriented. The rendezvous phase was subsequently replanned to the formerly-used two-day trajectory. Accordingly, TMA-12M arrived at the ISS on 27 March. The Soyuz remained docked to the ISS to serve as an emergency escape vehicle until undocking and landing as scheduled on 11 September 2014.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.