Soyuz TMA-06M was a spaceflight to the International Space Station launched on 23 October 2012, transporting three members of the Expedition 33 crew. TMA-06M was the 115th flight of a Soyuz spacecraft, the first flight launching in 1967. Soyuz TMA-06M launch was also the first crewed flight from the remote Site 31 pad since July 1984.

The Soyuz remained on board the space station for the Expedition 33 increment to serve as an emergency escape vehicle. Soyuz TMA-06M successfully returned to Earth on 15 March 2013.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.