Soyuz TMA-22 was a crewed spaceflight to the International Space Station (ISS). TMA-22 was the 111th flight of a Soyuz spacecraft, and transported three members of the Expedition 29 crew to the ISS. The spacecraft docked to the ISS on 16 November 2011, and remained docked to serve as an emergency escape vehicle until its undocking on 27 April 2012. Soyuz TMA-22 successfully landed in Kazakhstan on 27 April 2012 11:45 GMT.

TMA-22 was the final flight of a Soyuz-TMA vehicle, following the design's replacement by the modernized TMA-M series. The launch of Soyuz TMA-22 was originally scheduled for 30 September 2011, but was delayed until 14 November following the launch failure of the Progress M-12M resupply vehicle on 24 August 2011. Soyuz TMA-22 was the first crewed mission to dock with the ISS since the retirement of the American Space Shuttle fleet at the end of the STS-135 mission in July 2011.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.