Soyuz TMA-20 was a human spaceflight to the International Space Station (ISS) and was part of the Soyuz programme. It lifted off from the Baikonur Cosmodrome in Kazakhstan on December 15, 2010, and docked with the ISS two days later. The three-person crew of Soyuz TMA-20 – Dmitri Kondratyev, Catherine Coleman and Paolo Nespoli – represented the ISS partner organizations of Roscosmos, NASA and the European Space Agency (ESA). Soyuz TMA-20's crew represented half of the members of Expedition 27; the other three members of the expedition arrived at the station on board Soyuz TMA-21 on April 6, 2011. The COSPAR ID of Soyuz TMA-20 was 2010-067A. It is ISS flight 25S.

On May 24, 2011, after spending 159 days in space, the Soyuz TMA-20 descent module landed safely in Zhezkazgan, Kazakhstan, carrying Kondratyev, Coleman and Nespoli.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.