Starship Flight 10's objectives and flight profile are similar to those attempted on the previous several launches.

Ship 36, slated originally to support this launch, exploded during static fire testing at SpaceX's Masseys, a location they primarily use to complete proof testing of Ships and Boosters, and static fire testing of Ships. According to SpaceX, initial analysis indicated the failure, below proof pressure, of a composite overwrapped pressure vessel (COPV) containing gaseous nitrogen located within the Ship's nosecone area.

Following Ship 36's anomaly, which inflicted significant damage at Masseys, SpaceX modified the launch pad to support static fire testing of Ship 37 while repair work continued at Masseys.

Booster 16 will conduct several experiments before entering the ocean, including flipping in a controlled direction after stage separation, similar to that tested on Flight 9, and testing engine-out capability during the final landing burn.

Ship 37 is planned to deploy 8 Starlink simulators, similar in size to next-generation Starlink satellites, into the same suborbital trajectory as the Ship itself.