ISRO will conduct a second in-flight abort test of its future Gaganyaan crew spacecraft, boosted by a modified GSLV Mk. II booster. The capsule will include crew heat systems, a post-splashdown CM uprighting system, and even seats for the crew.

NASA astronauts will exit the Quest airlock and conduct a spacewalk outside the International Space Station (ISS).

The Cygnus NG-21 spacecraft will be released from the International Space Station ahead of a destructive reentry into Earth's atmosphere.