Following its launch aboard an Atlas V in 2021, NASA's Lucy spacecraft will fly past asteroid 52246 Donaldjohanson, a C-type asteroid in the main belt, at a distance of 596 miles (960 km). The flyby will serve as a dress rehearsal for Lucy's main mission: the exploration of multiple Jupiter Trojan asteroids.

Cargo Dragon CRS-32 will autonomously dock to the International Space Station (ISS).

The Shenzhou 19 Descent Capsule will land in the desert near Jiuquan Satellite Launch Center, China, bringing Cai Xuzhe, Song Lingdong and Wang Haozhe back to Earth after spending six months in orbit as part of the eighth mission to the Chinese Space Station.

NASA astronauts Anne McClain and Nichole Ayers will exit the Quest airlock and conduct a spacewalk outside the ISS to install a modification kit on the port side of the truss for the seventh iROSA (ISS Rollout Solar Array) and to relocate an antenna that communicates with approaching and departing spacecraft.

After its launch on SpaceX's Falcon 9 rocket, i-Space's HAKUTO-R Mission 2 Lunar Lander will land at Mare Frigoris.