The Cygnus NG-17 spacecraft will be released from the International Space Station ahead of a destructive reentry into Earth's atmosphere.

Russian cosmonauts Oleg Artemyev and Denis Matveev will work on the ERA robotic arm as part of the work scheduled to commission the Nauka module and robotic arm.

Cargo Dragon CRS-25 will dock autonomously to the zenith docking port of the Harmony module.

The DART spacecraft will achieve the kinetic impact deflection by deliberately crashing itself into Dimorphos at a speed of approximately 6.6 km/s. LICIACube will be carrying out observational analysis after DART's impact.

The OSIRIS-REx spacecraft will return a sample of the asteroid Bennu to Earth. The sample will land via parachute in the Utah desert.