NASA astronauts Nick Hague and Sunita Williams will exit the Quest airlock and conduct a spacewalk outside the ISS to replace a rate gyro assembly, install patches to cover damaged areas of light filters for the NICER X-ray telescope, and replace a reflector device used for navigational data on one of the international docking adapters.

NASA astronauts Sunita Williams and Barry Wilmore will exit the Quest airlock and conduct a spacewalk outside the ISS to remove a radio frequency group antenna assembly, collect modules exterior surface material samples for microorganisms analysis, and prepare a spare Canadarm2 elbow joint for future use.

ISRO will conduct a second in-flight abort test of its future Gaganyaan crew spacecraft, boosted by a modified GSLV Mk. II booster. The capsule will include crew heat systems, a post-splashdown CM uprighting system, and even seats for the crew.

The Cygnus NG-21 spacecraft will be released from the International Space Station ahead of a destructive reentry into Earth's atmosphere.