The Cygnus NG-18 spacecraft will be released from the International Space Station ahead of a destructive reentry into Earth's atmosphere.

NASA astronaut Nicole Mann and JAXA astronaut Koichi Wakata will exit the station’s Quest airlock to complete the installation of two mounting platforms as part of planned solar array augmentation on the starboard side of the International Space Station’s truss.

The Progress MS-20 cargo resupply vehicle will undock from the Zvezda module on the International Space Station. Following undocking, Progress will be deorbited and burn up in Earth's atmosphere.

Progress MS-22 spacecraft will dock autonomously to the aft docking port of the Zvezda module.

The Soyuz MS-23 spacecraft will dock autonomously to the zenith docking port of the Poisk module of the International Space Station to replace Soyuz MS-22, which suffered a thermal control system depressurization/leak on the ISS on December 15, 2022.

Russian cosmonauts Sergey Prokopyev and Dmitry Petelin will relocate a radiator from the Rassvet module to the Nauka multipurpose laboratory module.

Russian cosmonauts Sergey Prokopyev and Dmitry Petelin will relocate an Airlock from the Rassvet module to the Nauka multipurpose laboratory module.

Russian cosmonauts will relocate an airlock from the Rassvet module to the Nauka multipurpose laboratory module

The lunar lander, HAKUTO-R Mission 1, will land on the Moon, becoming the first private mission from Japan to reach the lunar surface. Inside it carries Rover Rashid, the first rover from the United Arab Emirates, which will explore the surface of the Moon.

The OSIRIS-REx spacecraft will return a sample of the asteroid Bennu to Earth. The sample will land via parachute in the Utah desert.