SpaceX's Crew Dragon spacecraft will dock to Harmony PMA-3 on the International Space Station with NASA Astronauts Doug Hurley and Bob Behnken on board. It will be the first time that a crewed U.S. spacecraft docks with the Space Station since 2011.

The core stage for NASA's first SLS rocket will perform a Green Run hotfire test on the B-2 test stand at NASA Stennis

OSIRIS-REx will move into position to collect a sample of asteroid Bennu's surface material. The spacecraft's sampling arm will then touch the surface for five seconds as part of the Touch-And-Go (TAG) sampling maneuver.

Two cosmonauts will perform a spacewalk on the International Space Station.

After collecting several samples of the asteroid Ryugu, and after dropping several objects on its surface, Hayabusa-2 will leave Ryugu in December 2019 to bring back the samples it has collected on the asteroid. The capsule containing them should land in the Australian desert just like the Hayabusa-1 mission.

Russia will remove the Pirs module from the International Space Station to free the location for the future Nauka module. The undocking will be performed by a Progress cargo craft. The two vehicles will then be deorbited – burning up in Earth's atmosphere.

The new Russian Nauka module will allow Russia to have an additional scientific module aboard the International Space Station. Nauka will dock at the port of the old Pirs module.

NASA's Perseverance Mars rover will land at Jezero crater on Mars. The mission will seek signs of habitable conditions on Mars in the ancient past, and will also search for evidence—or biosignatures—of past microbial life.

The Chinese Martian lander Huoxing-1 will land at Chryse Planitia on Mars. It will become the first Chinese object on Mars. The HX-1 lander also contains a small rover. (Image credit: Xinhua)

Callisto is a prototype vehicle for a reusable rocket being developed by CNES, DLR, and JAXA. It will liftoff from the Kourou base in French Guiana for a suborbital flight, before returning to land next to the launch pad.

Thémis is a reusable launcher demonstrator developed by CNES and ESA. It must liftoff from Kourou with three methane-powered Prometheus engines, and return to land on a recovery barge.

ExoMars is a Martian rover of the European Space Agency that will land in the region of Oxia Planum. The rover will investigate the local geology and search for signs of past and present life.

The OSIRIS-REx spacecraft will return a sample of the asteroid Bennu to Earth. The sample will land via parachute in the Utah desert.