Cargo Dragon CRS-31 will undock autonomously from the Harmony module on the International Space Station after a one-month stay, orbit the Earth, and then splash down in the Gulf of Mexico or the Atlantic Ocean.

Russian cosmonauts Aleksey Ovchinin and Ivan Vagner will perform an EVA on the International Space Station which is planned to last around 6 hours and 40 minutes.

ISRO will conduct a second in-flight abort test of its future Gaganyaan crew spacecraft, boosted by a modified GSLV Mk. II booster. The capsule will include crew heat systems, a post-splashdown CM uprighting system, and even seats for the crew.

NASA astronauts will exit the Quest airlock and conduct a spacewalk outside the International Space Station (ISS).

The Cygnus NG-21 spacecraft will be released from the International Space Station ahead of a destructive reentry into Earth's atmosphere.