Cygnus NG-10 (Northrop Grumman-10) is a cargo resupply mission of the Northrop Grumman Cygnus spacecraft to the International Space Station under the Commercial Resupply Services (CRS) contract with NASA.

Northrop Grumman and NASA jointly developed a new space transportation system to provide commercial cargo resupply services to the International Space Station. The Cygnus cargo ship consists of two parts, a service module built in the USA based on the GEOStar platform, and a pressurized module, manufactured in France and Italy by Thales Alenia. The cargo is sent into orbit by a launcher specially developed for this purpose.

Antares has a first stage based on Energiya lateral blocks, made in Ukraine by Yuzhnoye. It was initially powered by two NK-33s, built in the 1960s for the Soviet N1 lunar launcher, before being replaced by RD-181s, derived from the RD-170s installed on Energiya and Zenit. The second stage, a Castor-30, is made in the USA, by Northrop Grumman.

CRS NG-10 was captured by RMS on 19/11/2018 at 10:28 UTC and berthed to the Nadir port of the Unity module of the International Space Station on 19/11/2018 at 12:31 UTC. Its stay on the ISS was 81 days. It was unberthed on 08/02/2019 at 14:37 UTC and released by RMS on 08/02/2019 at 16:16 UTC. It deorbited on 25/02/2019 at 09:05 UTC.