Soyuz TMA-16M was a 2015 flight to the International Space Station. It transported three members of the Expedition 43 crew to the Station. TMA-16M was the 125th flight of a Soyuz spacecraft, the first having launched in 1967.

Scott Kelly and Mikhail Korniyenko performed the first one-year stay at the Space Station, returning in Soyuz TMA-18M.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.