Soyuz TMA-01M was a Soyuz flight that transported three members of the Expedition 25 crew to the International Space Station. TMA-01M was the 107th flight of a Soyuz spacecraft, and the first flight of the modernized TMA-M series. The spacecraft remained docked to the space station during Expedition 25, to serve as an emergency escape vehicle.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.