Soyuz TMA-19 was a crewed spaceflight to the International Space Station (ISS) and is part of the Soyuz programme. It was launched on 15 June 2010 carrying three members of the Expedition 24 crew to the International Space Station, who remained aboard the station for around six months. Soyuz TMA-19 was the 106th crewed flight of a Soyuz spacecraft, since the first mission which was launched in 1967. The spacecraft remained docked to the space station for the remainder of Expedition 24, and for Expedition 25, to serve as an emergency escape vehicle. It undocked from ISS and landed in Kazakhstan on 26 November 2010. It was the 100th mission to be conducted as part of the International Space Station programme since assembly began in 1998.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.