The Soyuz TMA-14 (Russian: Союз ТМА-14, Union TMA-14) was a Soyuz flight to the International Space Station, which launched on 26 March 2009. It transported two members of the Expedition 19 crew as well as spaceflight participant Charles Simonyi on his second self-funded flight to the space station. TMA-14 was the 101st crewed flight of a Soyuz spacecraft, including launch failures; however, it was the 100th to launch and land crewed, as Soyuz 34 was launched uncrewed to replace Soyuz 32, which landed empty.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.