Soyuz TMA-12 was a Soyuz mission to the International Space Station (ISS) which was launched by a Soyuz FG rocket at 11:16 UTC on 8 April 2008. It docked to the Pirs module of the station on 10 April 2008. Landing occurred at 03:37 on 24 October. It was the first nominal landing in three missions, following separation failures on the Soyuz TMA-10 and 11 spacecraft.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.