Soyuz TMA-4 was a Soyuz mission to the International Space Station (ISS) launched by a Soyuz FG launch vehicle. It was launched on April 19, 2004 (UTC) from Baikonur Cosmodrome. Gennady Padalka from Russia, Michael Fincke from the US and André Kuipers from the Netherlands were flown to the International Space Station. Kuipers returned to Earth 9 days later together with ISS crew 8 with the re-entry module of the Soyuz TMA-3, the other two stayed as ISS crew 9. The craft landed October 24, 2004 with Padalka, Fincke and Yuri Shargin aboard.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.