Soyuz TM-4 was the fourth crewed spacecraft to dock with the space station Mir. It was launched in December 1987, and carried the first two crew members of the third long duration expedition, Mir EO-3. These crew members, Vladimir Titov and Musa Manarov, would stay in space for just under 366 days, setting a new spaceflight record. The third astronaut launched by Soyuz TM-4 was Anatoli Levchenko, who returned to Earth about a week later with the remaining crew of Mir EO-2. Levchenko was a prospective pilot for the Soviet Space shuttle Buran. The purpose of his mission, named Mir LII-1, was to familiarize him with spaceflight.

It was the fourth Soyuz TM spacecraft to be launched (one of which wasn't crewed), and like other Soyuz spacecraft, it was treated as a lifeboat for the station's crew while docked. In June 1988, part way through EO-3, Soyuz TM-4 was swapped for Soyuz TM-5 as the station's lifeboat. The mission which swapped the spacecraft was known as Mir EP-2, and had a three-person crew.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.