Soyuz TM-5 was the fifth cosmonaut-carrying spacecraft to visit the Russian Space Station Mir. It was launched on June 7, 1988, carrying the Mir EP-2 mission's three-person crew. This week-long stay on Mir occurred during the third long-duration Mir expedition, Mir EO-3. The crew of EP-2 returned to Earth aboard Soyuz TM-4, while the TM-5 spacecraft remained docked to Mir, acting as the lifeboat for the long-duration crew. On September 7, 1988, the TM-5 spacecraft undocked from Mir, and landed Mir EP-3 mission's two-person visiting crew. The de-orbit procedures for Soyuz were revised after this flight, as multiple issues almost prevented the descent module's safe de-orbit and landing.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.