Soyuz TM-7 was the seventh crewed spacecraft to dock with the Soviet Space Station Mir. Its launch in November 1988 represented the start of the fourth long duration expedition, Mir EO-4, as it carried two more Soviet cosmonauts, Sergei Krikalev and Alexander Volkov, to the station. They would join the third crew member of EO-4, cosmonaut/physician Valeri Polyakov, who was on Mir for the second half of EO-3. Also launched by Soyuz TM-7 was French astronaut Jean-Loup Chrétien, who would take part in the 24-day French mission known as Mir Aragatz. The spacecraft Soyuz TM-7 remained docked to Mir for the duration of EO-4. At the end of EO-4 in April 1989, due to delays in the launch schedule, Mir was left uncrewed, and all three EO-4 crew members were transported back to Earth.

The Soyuz is a Soviet crewed spacecraft, developed to perform lunar missions with crew. This version called 7K will fly 4 times on the giant launcher N1, and several tens of times on Proton to fly over the Moon, which will be successful during the mission Zond 4. Soyuz will become the first spacecraft to transport living beings on the Moon during the flight of Zond 5, with two turtles. Thereafter, it is adapted to the low orbit and will fly on the Soyuz launcher to supply the Soviet Salyut and Mir stations, and the ISS.